Revisão da dermatite atópica canina: um olhar da conformação da pele e sua resposta imune
DOI:
https://doi.org/10.38017/22487735.616Palavras-chave:
atopia, colágeno, estrato corneano, hipersensibilidade tipo I, hipersensibilidade tipo IVResumo
Dermatite são patologias frequentes na consulta de pequenos animais, sendo uma condição inespecífica que ameaça o bem-estar de cães e felinos e afeta a dinâmica da família desses indivíduos. Dentro do grupo de dermatite, o atópico tornou-se uma condição difícil de diagnóstico e tratamento. Sabe-se que a dermatite atópica canina (ACD) é multifatorial e depende da predisposição genética de indivíduos e estímulos ambientais, que podem ser afetados pelas mudanças climáticas. A resposta imune complexa nos caninos nos permitiu entender a dermatite atópica humana, tornando-se um modelo médico para pesquisa. Essa inflamação alérgica é mediada por uma resposta de hipersensibilidade tipo I ou IV, sendo semelhante em cães e humanos. Os mastócitos, células com presença importante na pele canina, facilitam o recrutamento de leucócitos, favorecem a adesão e a diapedese dessas células, permitindo que a resposta inflamatória seja exagerada. Nas citosinas de resposta imune, fator de necrose tumoral, natural killer, entre outros, que facilitam a comunicação entre a imunologia inata e adquirida, levando à resposta imune complexa e permitindo que a resposta imune-mediada ocorra. Além disso, a partir da resposta imune individual, o DCA pode ser complicado pela contaminação secundária de microrganismos, que levam a suas próprias respostas imunes, dependendo de sua natureza. Este documento pretende expor da conformação anatômica da pele e de sua resposta imune a apresentação da DCA.
Biografia do Autor
Ana Consuelo González Patiño, Fundación Universitaria Juan de Castellanos
Médico Veterinario y Zootecnista, Universidad de los Llanos
M.Sc. en Ciencias Veterinarias, Universidad Pedagógica y Tecnológica de Colombia
Docente, Facultad de Ciencias Agrarias y Ambientales, Fundación Universitaria Juan de Castellanos, Grupo de investigación IRABI.
Rosa María Viviana Gómez Carrillo, Fundación Universitaria Juan de Castellanos
Médico Veterinario, Universidad de Ciencias Aplicadas y Ambientales
M.Sc. en Conservación y Manejo de Vida Silvestre, Universidad Nacional de Costa Rica
Docente, Facultad de Ciencias Agrarias y Ambientales. Fundación Universitaria Juan de Castellanos, Grupo de investigación IRABI.
Miguel Ángel Ardila Páez, Fundación Universitaria Juan de Castellanos
Estudiante X semestre Medicina Veterinaria, Facultad de Ciencias Agrarias y Ambientales, Fundación Universitaria Juan de Castellanos, Grupo de investigación IRABI.
Yohana Milena López Róbles, Fundación Universitaria Juan de Castellanos
Médico Veterinario, Fundación Universitaria Juan de Castellanos
M.Sc (e) en Ciencias Veterinarias, Universidad Pedagógica y Tecnológica de Colombia, Grupo de investigación GIDIMEVETZ
Docente, Facultad de Ciencias Agrarias y Ambientales, Fundación Universitaria Juan de Castellanos.
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